Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TCF-1-mediated Wnt signaling regulates Paneth cell innate immune defense effectors HD-5 and -6: implications for Crohn's disease

4 Jul 2014

Abstract excerpt

Wnt signaling regulates small intestinal stem cell maintenance and Paneth cell differentiation. In patients with ileal Crohn's disease (CD), a decrease of Paneth cell α-defensins has been observed that is partially caused by impaired TCF-4 and LRP6 function. Here we show reduced expression of the Wnt signaling effector TCF-1 (also known as TCF-7) in patients with ileal CD. Reporter gene assays and in vitro...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Digestive system and related health
Share to Helicobacter pylori-related gastroenterology studies
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24994854
DOI: 10.1152/ajpgi.00347.2013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TCF-1-mediated Wnt signaling regulates Paneth cell innate immune defense effectors HD-5 and -6: implications for Crohn's diseasePMID 24994854Read ↗

The Paneth Cell α-Defensin Deficiency of Ileal Crohn’s Disease Is Linked to Wnt/Tcf-4Semantic proximity Read ↗

Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease.Semantic proximity Read ↗

Paneth's disease.Semantic proximity Read ↗

Tcf4 regulates secretory cell fate decisions in the small intestine and colon tumors: insights from transcriptomic, histological, and microbiome analysesSemantic proximity Read ↗

Wnt/β-catenin activation epigenetically reprograms Regulatory T cells in IBD and progression to dysplasia.Semantic proximity Read ↗

Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease.Semantic proximity Read ↗

WNT signaling in the normal intestine and colorectal cancer.Semantic proximity Read ↗

Crohn's disease-derived monocytes fail to induce Paneth cell defensinsSemantic proximity Read ↗

MicroRNA-449a Overexpression, Reduced NOTCH1 Signals and Scarce Goblet Cells Characterize the Small Intestine of Celiac PatientsSemantic proximity Read ↗

Wnt-β-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression.Semantic proximity Read ↗

Wnt/β-Catenin Is Essential for Intestinal Homeostasis and Maintenance of Intestinal Stem CellsSemantic proximity Read ↗

Host-microbe interaction: mechanisms of defensin deficiency in Crohn's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.