Article

Tissue-embedded CD4⁺ plasticity defines mucosal immunity in Inflammatory Bowel Disease

2025-11-02

Abstract excerpt

CD4⁺ T helper (Th) cell responses to commensal microbiota are linked to Inflammatory Bowel Disease (IBD), yet how Th programs coexist and evolve in human tissues remains poorly defined. Here, we profiled CD4⁺ memory T cells in intestinal biopsies using immunological and histological approaches to map their phenotypes, functional states, and spatial relationships across disease states. A marked expansion of CD4⁺ T...

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Literature Corpus work: cdd62bd0-d40c-52c4-95e6-c2093ddfa6e4
DOI: 10.1101/2025.10.31.685649

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