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Paraquat Licences α-Synuclein to Trigger NLRP3-Dependent Pyroptosis in Microglia

2025-07-27

Abstract excerpt

Parkinson’s disease (PD) is characterized by dopaminergic neurodegeneration and the pathological accumulation of α-synuclein (αSyn) aggregates. While its etiology is multifactorial, environmental toxicants such as paraquat, a widely used herbicide banned in over 70 countries but still permitted in some regions, including Australia, are strongly implicated. We previously showed that αSyn activates the NLRP3 inflamm...

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Identifiers and source

Literature Corpus work
1e9d6589-c9f3-5d7f-8d7a-bec1f251d511
DOI
10.1101/2025.07.23.666340
Open publication

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Paraquat Licences α-Synuclein to Trigger NLRP3-Dependent Pyroptosis in MicrogliaDOI 10.1101/2025.07.23.666340
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