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Article

Activated microglia contribute to paraquat neurotoxicity through neuroinflammation and regulation of phenotypic polarization of astrocytes.

Ecotoxicology and environmental safety - 1 May 2026

Yang Huiming, Yang Yi, Yang Lili, Li Zheng, Lyu Liang, Zhang Xiaofeng

Abstract excerpt

Paraquat (PQ), a widely used bipyridyl herbicide, exerts neurotoxic effects on dopaminergic neurons and can lead to Parkinson's disease (PD)-like syndrome. Although immune dysfunction has been implicated in PD progression, the role of neuroimmune interactions in PQ-induced neurotoxicity remains poorly understood. This study aimed to investigate the mechanism by which microglia, the innate immune cells of the...

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PMID: 41966020
DOI: 10.1016/j.ecoenv.2026.120120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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