Article

Parkinson’s disease-derived α-Synuclein assemblies combined with chronic-type inflammatory cues promote a neurotoxic microglial phenotype

2023-12-01

Abstract excerpt

Parkinson’s disease (PD) is a common age-related neurodegenerative disorder characterized by the aggregation of α-synuclein (αSYN) building up intraneuronal inclusions termed Lewy pathology. Mounting evidence suggests that neuron-released αSYN aggregates could be central to microglial activation, which in turn mounts and orchestrates neuroinflammatory processes potentially harmful to neurons. Therefore, understand...

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Literature Corpus work: 06cc701d-8459-5d7c-b6f4-ad5d763bf15e
DOI: 10.1101/2023.11.30.569208

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