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Article

Nuclear ASC speck formation in microglia is associated with inflammasome priming and is exacerbated in LRRK2-G2019S Parkinson's disease.

Neurobiology of disease - 1 Jan 2026

Ballotto Luca, Baratta Thomas, Winterberg Helena, Dusanter Cédric, Sambin Sara, Corvol Jean Christophe, Iovino Ludovica, Bubacco Luigi, Corti Olga, Greggio Elisa, Novello Salvatore

Abstract excerpt

Neuroinflammation is increasingly recognized as a central pathological mechanism in Parkinson's disease (PD), a progressive neurodegenerative disorder marked by dopaminergic neuron loss and diverse motor and non-motor symptoms. The NLRP3 inflammasome and its adaptor protein ASC are critical to initiating and sustaining inflammatory responses in the central nervous system. Although acute inflammasome activation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41455502
DOI: 10.1016/j.nbd.2025.107237

Genes

NLRP3

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PubMed metadata and Literature Corpus relationships.

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