Article

Microglial GSDMD-Mediated Pyroptosis Drives Neuroinflammation in Parkinson’s Disease

2025-07-04

Abstract excerpt

<h4>Rationale</h4> Parkinson’s disease (PD), a globally prevalent neurodegenerative disorder, is characterized by substantia nigra dopaminergic neuron degeneration and striatal dopamine depletion. While microglial pyroptosis is implicated in neuroinflammation and neural injury via inflammatory cytokine release, the role of the CASPASE-1/GSDMD pathway in PD pathogenesis remains incompletely defined. <h4>Methods</h...

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Literature Corpus work: 711b4253-a923-5b27-acb8-dd0e6c09ba72
DOI: 10.1101/2025.06.30.662314

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