Article
O-GlcNAcylation of SKN-1 modulates the lifespan and oxidative stress resistance in Caenorhabditis elegans.
Scientific reports - 8 Mar 2017
Li Hongyuan, Liu Xin, Wang Dan, Su Liangping, Zhao Tingting, Li Zhongwei, Lin Cong, Zhang Yu, Huang Baiqu, Lu Jun, Li Xiaoxue
Abstract excerpt
In C. elegans, the transcription factor skinhead-1 (SKN-1), the ortholog of human NF-E2-related factor 2 (Nrf-2), plays important roles in oxidative stress defense and aging processes. It has been documented that the activity of SKN-1 is regulated by its phosphorylation modification. However, whether other posttranslational modifications of SKN-1 affect its function remains unclear to date. Here we report, for...
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