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Article

The XBP1-MARCH5-MFN2 Axis Confers ER Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma

2020-12-15

Abstract excerpt

<h4>Background: </h4> Melanoma cells are relatively resistant to ER stress, which contributes to tumor progression under stressful conditions and renders tolerance to ER stress-inducing therapeutic agents. Mitochondria are tightly interconnected with ER. However, whether mitochondria play a role in regulating ER stress resistance in melanoma remains elusive. <h4>Methods: </h4>: Integrative bioinformatics was emplo...

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Literature Corpus work
883a8fcc-d32c-5795-8b66-1cce61c8e166
DOI
10.21203/rs.3.rs-125319/v1
Open publication

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