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Article

Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans.

Cell reports - 29 Aug 2017

Edifizi Diletta, Nolte Hendrik, Babu Vipin, Castells-Roca Laia, Mueller Michael M, Brodesser Susanne, Krüger Marcus, Schumacher Björn

Abstract excerpt

DNA damage causally contributes to aging and age-related diseases. Mutations in nucleotide excision repair (NER) genes cause highly complex congenital syndromes characterized by growth retardation, cancer susceptibility, and accelerated aging in humans. Orthologous mutations in Caenorhabditis elegans lead to growth delay, genome instability, and accelerated functional decline, thus allowing investigation of the...

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Identifiers

PMID: 28854356
DOI: 10.1016/j.celrep.2017.08.028
PMCID: PMC5583510

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EGF

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Source receipt: pubmed, retrieved 7 Sept 2026.

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