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Article

The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegans.

PLoS genetics - 1 Mar 2013

Staab Trisha A, Griffen Trevor C, Corcoran Connor, Evgrafov Oleg, Knowles James A, Sieburth Derek

Abstract excerpt

The Nrf family of transcription factors plays a critical role in mediating adaptive responses to cellular stress and defends against neurodegeneration, aging, and cancer. Here, we report a novel role for the Caenorhabditis elegans Nrf homolog SKN-1 in regulating synaptic transmission at neuromuscular junctions (NMJs). Activation of SKN-1, either by acute pharmacological treatment with the mitochondrial toxin...

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Identifiers

PMID: 23555279
DOI: 10.1371/journal.pgen.1003354
PMCID: PMC3605294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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