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Article

The unfolded protein response impacts melanoma progression by enhancing FGF expression and can be antagonized by a chemical chaperone.

Scientific reports - 13 Dec 2017

Eigner Karin, Filik Yüksel, Mark Florian, Schütz Birgit, Klambauer Günter, Moriggl Richard, Hengstschläger Markus, Stangl Herbert, Mikula Mario, Röhrl Clemens

Abstract excerpt

The mechanisms hallmarking melanoma progression are insufficiently understood. Here we studied the impact of the unfolded protein response (UPR) - a signalling cascade playing ambiguous roles in carcinogenesis - in melanoma malignancy. We identified isogenic patient-derived melanoma cell lines harboring BRAFV600E-mutations as a model system to study the role of intrinsic UPR in melanoma progression. We show that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29235576
DOI: 10.1038/s41598-017-17888-9
PMCID: PMC5727496

Genes

ATF6
FGF1
FGF2

Provenance

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