Article

Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras

2009-11-06

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we determined the effect of PDAC-relevant gene mutations in distinct cell types of the adult pancreas. We show that a subpopulation of Pdx1-expressing cells is susceptible to oncogenic K-Ras induced transformation without tissue injury, whereas insulin-expressing endocrine cel...

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Literature Corpus work: 1e7cad8a-adad-5351-8d1e-8f76955ac320
DOI: 10.1016/j.ccr.2009.09.027

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