Article
Dynamic Regulation of Expression of KRAS and Its Effectors Determines the Ability to Initiate Tumorigenesis in Pancreatic Acinar Cells.
Cancer research - 15 May 2021
Assi Mohamad, Achouri Younes, Loriot Axelle, Dauguet Nicolas, Dahou Hajar, Baldan Jonathan, Libert Maxime, Fain Jean S, Guerra Carmen, Bouwens Luc, Barbacid Mariano, Lemaigre Frédéric P, Jacquemin Patrick
Abstract excerpt
Pancreatic acinar cells are a cell type of origin for pancreatic cancer that become progressively less sensitive to tumorigenesis induced by oncogenic Kras mutations after birth. This sensitivity is increased when Kras mutations are combined with pancreatitis. Molecular mechanisms underlying these observations are still largely unknown. To identify these mechanisms, we generated the first CRISPR-edited mouse...
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