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Article

Ras activity levels control the development of pancreatic diseases.

Gastroenterology - 1 Sept 2009

Ji Baoan, Tsou Lilian, Wang Huamin, Gaiser Sebastian, Chang David Z, Daniluk Jaroslaw, Bi Yan, Grote Tobias, Longnecker Daniel S, Logsdon Craig D

Abstract excerpt

BACKGROUND & AIMS: Differentiated pancreatic acinar cells expressing endogenous levels of mutant K-Ras do not spontaneously develop pancreatic ductal adenocarcinoma (PDAC). However, we hypothesized that acinar cells would develop PDAC in the presence of Ras activity levels mimicking those of human tumor cells. METHODS: We measured Ras activity in PDAC cells from mice and humans using a Raf pull-down assay. We...

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Share to Carcinoma, Pancreatic Ductal
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, ras

Share to Mice, Transgenic

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Share to Pancreatic Neoplasms

Share to Pancreatitis, Chronic

Source

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Identifiers

PMID: 19501586
DOI: 10.1053/j.gastro.2009.05.052
PMCID: PMC2789008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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