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Article

Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.

Cancer cell - 1 Mar 2007

Guerra Carmen, Schuhmacher Alberto J, Cañamero Marta, Grippo Paul J, Verdaguer Lena, Pérez-Gallego Lucía, Dubus Pierre, Sandgren Eric P, Barbacid Mariano

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDA), one of the deadliest human cancers, often involves somatic activation of K-Ras oncogenes. We report that selective expression of an endogenous K-Ras(G12V) oncogene in embryonic cells of acinar/centroacinar lineage results in pancreatic intraepithelial neoplasias (PanINs) and invasive PDA, suggesting that PDA originates by differentiation of acinar/centroacinar cells or...

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Identifiers

PMID: 17349585
DOI: 10.1016/j.ccr.2007.01.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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