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Article

The Significance of Ras Activity in Pancreatic Cancer Initiation

1 Jan 2016

Abstract excerpt

The genetic landscape of pancreatic cancer shows nearly ubiquitous mutations of K-RAS. However, oncogenic K-Ras(mt) alone is not sufficient to lead to pancreatic ductal adenocarcinoma (PDAC) in either human or in genetically modified adult mouse models. Many stimulants, such as high fat diet, CCK, LPS, PGE2 and others, have physiological effects at low concentrations that are mediated in part through modest...

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PMID: 26929740
DOI: 10.7150/ijbs.15020

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