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Article

Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α.

Genes & development - 1 Dec 2014

Baer Romain, Cintas Célia, Dufresne Marlène, Cassant-Sourdy Stéphanie, Schönhuber Nina, Planque Laetitia, Lulka Hubert, Couderc Bettina, Bousquet Corinne, Garmy-Susini Barbara, Vanhaesebroeck Bart, Pyronnet Stéphane, Saur Dieter, Guillermet-Guibert Julie

Abstract excerpt

Increased PI 3-kinase (PI3K) signaling in pancreatic ductal adenocarcinoma (PDAC) correlates with poor prognosis, but the role of class I PI3K isoforms during its induction remains unclear. Using genetically engineered mice and pharmacological isoform-selective inhibitors, we found that the p110α PI3K isoform is a major signaling enzyme for PDAC development induced by a combination of genetic and nongenetic...

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Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25452273
DOI: 10.1101/gad.249409.114
PMCID: PMC4248293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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