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Article

KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin.

Molecular cancer research : MCR - 1 Feb 2009

Shi Chanjuan, Hong Seung-Mo, Lim Phillip, Kamiyama Hirohiko, Khan Mehtab, Anders Robert A, Goggins Michael, Hruban Ralph H, Eshleman James R

Abstract excerpt

Pancreatic intraepithelial neoplasia (PanIN) is a precursor to invasive ductal adenocarcinoma of the pancreas. Observations made in genetically engineered mouse models suggest that the acinar/centroacinar compartment can give rise to ductal neoplasia. To integrate findings in mice and men, we exa...

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Identifiers

PMID: 19208745
DOI: 10.1158/1541-7786.MCR-08-0206
PMCID: PMC2708114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19208745-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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