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Article

Hedgehog/Ras interactions regulate early stages of pancreatic cancer.

Genes & development - 15 Nov 2006

Pasca di Magliano Marina, Sekine Shigeki, Ermilov Alexandre, Ferris Jenny, Dlugosz Andrzej A, Hebrok Matthias

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDA) constitutes a lethal disease that affects >30,000 people annually in the United States. Deregulation of Hedgehog signaling has been implicated in the pathogenesis of PDA. To gain insights into the role of the pathway during the distinct stages of pancreatic carcinogenesis, we established a mouse model in which Hedgehog signaling is activated specifically in the pancreatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17114586
DOI: 10.1101/gad.1470806
PMCID: PMC1635150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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