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New Cell Cycle Inhibitors Target Aneuploidy in Cancer Therapy

15 Aug 2018

Abstract excerpt

Aneuploidy is a hallmark of cancer. Defects in chromosome segregation result in aneuploidy. Multiple pathways are engaged in this process, including errors in kinetochore-microtubule attachments, supernumerary centrosomes, spindle assembly checkpoint (SAC) defects, and chromosome cohesion defects. Although aneuploidy provides an adaptation and proliferative advantage in affected cells, excessive aneuploidy beyond...

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PMID: 30110577
DOI: 10.1146/annurev-pharmtox-010818-021649

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