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Article

Unraveling pathologies underlying chromosomal instability in cancers.

Cancer science - 1 Aug 2021

Jo Minji, Kusano Yoshiharu, Hirota Toru

Abstract excerpt

Aneuploidy is a widespread feature of malignant tumors that arises through persistent chromosome mis-segregation in mitosis associated with a pathological condition called chromosomal instability, or CIN. Since CIN is known to have a causal relationship with poor prognosis accompanying by multi-drug resistance, tumor relapse, and metastasis, many research groups have endeavored to understand the mechanisms...

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Identifiers

PMID: 34032342
DOI: 10.1111/cas.14989
PMCID: PMC8353923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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