Article

The Undervalued Avenue to Reinstate Tumor Suppressor Functionality of the p53 Protein Family for Improved Cancer Therapy - Drug Repurposing

2020-09-17

Abstract excerpt

p53 and p73 are critical tumor suppressors often inactivated in human cancers through various mechanisms. Owing to high structural homology, the proteins have many common functions and recognize the same set of genes involved in apoptosis and cell cycle regulation. p53 is known as the ‘guardian of the genome’ and together with p73 form a barrier against cancer development and progression. The TP53 is m...

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Literature Corpus work: 1dc8b4f1-fabd-5570-b412-fc4f7ac7ca3f
DOI: 10.20944/preprints202008.0729.v2

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