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Article

Reviving the guardian of the genome: Small molecule activators of p53.

Pharmacology & therapeutics - 1 Oct 2017

Nguyen Daniel, Liao Wenjuan, Zeng Shelya X, Lu Hua

Abstract excerpt

The tumor suppressor p53 is one of the most important proteins for protection of genomic stability and cancer prevention. Cancers often inactivate it by either mutating its gene or disabling its function. Thus, activating p53 becomes an attractive approach for the development of molecule-based anti-cancer therapy. The past decade and half have witnessed tremendous progress in this area. This essay offers readers...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28351719
DOI: 10.1016/j.pharmthera.2017.03.013
PMCID: PMC5601031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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