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Article

Unraveling the Guardian: p53's Multifaceted Role in the DNA Damage Response and Tumor Treatment Strategies.

International journal of molecular sciences - 1 Dec 2024

Zhang Han, Xu Jianxiong, Long Yuxuan, Maimaitijiang Ayitila, Su Zhengding, Li Wenfang, Li Jinyao

Abstract excerpt

DNA damage can lead to mutations that can alter the function of oncogenes or tumor suppressor genes, thus promoting the development of cancer. p53 plays a multifaceted and complex role in the DNA damage response and cancer progression and is known as the 'guardian of the gene'. When DNA damage occurs, p53 is activated through a series of post-translational modifications, which stabilize the protein and enhance...

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Identifiers

PMID: 39684639
DOI: 10.3390/ijms252312928
PMCID: PMC11641486

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