Article
p53: from understanding its structure to advances in therapeutic targeting.
Signal transduction and targeted therapy - 6 Apr 2026
Wang Wenhua, Liu Xia, Liu Hengqi, Abolhassani Hassan, Yan Han, Zhang Huilai, Wang Xianhuo
Abstract excerpt
The tumor suppressor gene TP53 is the most frequently mutated gene in human cancers and has been a popular area of research in the field of oncology. The p53 protein, encoded by the TP53 gene, not only binds to many targeted genes but also regulates apoptosis, autophagy, cell cycle arrest, metabolism, senescence and the tumor immune microenvironment to suppress tumorigenesis. In recent years, an increasing number...
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