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Article

From tumor prevention to therapy: empowering p53 to fight back.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Oct 2012

Frezza Christian, Martins Carla P

Abstract excerpt

The p53 transcription factor was first described over three decades ago and is one of the most studied proteins, with over 60,000 PubMed listed publications. Despite being first described as an oncogene, p53 has long been recognized as a major tumor suppressor and the most commonly mutated gene in human cancer. The frequent inactivation of p53 in tumors fostered the attractive notion that its functional...

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PMID: 23164556
DOI: 10.1016/j.drup.2012.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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