Article
Methods for screening tumors for p53 status and therapeutic exploitation.
Expert review of molecular diagnostics - 1 May 2003
Tullo Apollonia, D'Erchia Anna Maria, Sbisà Elisabetta
Abstract excerpt
Mutations in the p53 oncosuppressor gene occur in most human cancers and regulation of the protein is defective in a variety of others. Novel strategies are emerging for the treatment of tumors that have p53 mutations. In this context, the analysis of p53 status is useful in diagnosis and prognosis, and could serve to evaluate the effectiveness of a cancer treatment. In this review, we report an overview of major...
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