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Discovery of Drugs Targeting Mutant p53 and Progress in Nano-Enabled Therapeutic Strategy for p53-Mutated Cancers.

Biomolecules - 26 May 2025

Zhang Na, Jing Zhiyuan, Song Jie, Liang Qiyue, Xu Yuxue, Xu Zhaowei, Wen Longping, Wei Pengfei

Abstract excerpt

Mutations in the p53 gene are frequently observed in various cancers, prompting the initiation of efforts to restore p53 function as a therapeutic approach several decades ago. Nevertheless, only a limited number of drug development initiatives have progressed to late-stage clinical trials, and to date, no p53-targeted therapies have received approval in the USA or Europe. This situation can be attributed...

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Identifiers

PMID: 40563405
DOI: 10.3390/biom15060763
PMCID: PMC12190563

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