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Targeting Tumor Suppressor p53 for Cancer Therapy: Strategies, Challenges and Opportunities

31 Jan 2014

Abstract excerpt

p53 is one of the most important tumor suppressor genes that is frequently mutated in human cancers. Generally, p53 functions as a transcription factor that is stabilized and activated by various genotoxic and cellular stress signals, such as DNA damage, hypoxia, oncogene activation and nutrient deprivation, consequently leading to cell cycle arrest, apoptosis, senescence and metabolic adaptation. p53 not only...

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PMID: 24387333
DOI: 10.2174/1389450114666140106101412

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