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Article

An overview of the functions of p53 and drugs acting either on wild- or mutant-type p53.

European journal of medicinal chemistry - 5 Feb 2024

Huang Yongmi, Jiao Zhihao, Fu Yuqing, Hou Yue, Sun Jinxiao, Hu Feiran, Yu Shangzhe, Gong Kexin, Liu Yiru, Zhao Guisen

Abstract excerpt

TP53, also known as the "guardian of the genome," is an important tumor suppressor gene. It is encoded by the human genome and is associated with the development of diverse cancers. The p53 protein, encoded by TP53, functions in the cell to monitor DNA damage and prompts the cell to respond appropriately. When DNA is damaged, p53 halts the cell cycle, allowing cells to enter the repair state. If the repair is...

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PMID: 38194777
DOI: 10.1016/j.ejmech.2024.116121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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