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Targeting the p53 signaling pathway in cancer therapy – the promises, challenges and perils

1 Jan 2012

Abstract excerpt

INTRODUCTION: Research over the past three decades has identified p53 as a multi-functional transcription factor. p53 influences myriad, highly diverse cellular processes, and represents one of the most important and extensively studied tumor suppressors. Activated by various stresses, p53 blocks cancer progression by provoking transient or permanent growth arrest, by enabling DNA repair, or by advancing cellular...

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PMID: 22239435
DOI: 10.1517/14728222.2011.643299

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