Article

Next-generation CRISPR gene-drive systems using Cas12a nuclease

2023-02-20

Abstract excerpt

<h4>ABSTRACT</h4> One method for reducing the impact of vector-borne diseases is through the use of CRISPR-based gene drives, which manipulate insect populations due to their ability to rapidly propagate desired genetic traits into a target population. However, all current gene drives employ a Cas9 nuclease that is constitutively active, impeding our control over their propagation abilities and limiting the gener...

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Literature Corpus work: 46db3cff-9ad3-58ca-95c3-788c56c89766
DOI: 10.1101/2023.02.20.529271

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