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CSF proteomic profiling with amyloid/tau positivity identifies distinctive sex-different alteration of multiple proteins involved in Alzheimer’s disease

2024-03-16

Abstract excerpt

In Alzheimer’s disease (AD), the most common cause of dementia, females have higher prevalence and faster progression, but sex-specific molecular findings in AD are limited. Here, we comprehensively examined and validated 7,006 aptamers targeting 6,162 proteins in cerebral spinal fluid (CSF) from 2,077 amyloid/tau positive cases and controls to identify sex-specific proteomic signatures of AD. In discovery (N=1,76...

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Literature Corpus work
b2b1e8e2-32df-5f6d-a2c7-d4dd151228a6
DOI
10.1101/2024.03.15.24304164
Open publication

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CSF proteomic profiling with amyloid/tau positivity identifies distinctive sex-different alteration of multiple proteins involved in Alzheimer’s diseaseDOI 10.1101/2024.03.15.24304164
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