Article

Engineered heart tissues facilitate functional characterization of noncoding variants implicated in Hypertrophic and Dilated Cardiomyopathy

2025-09-25

Abstract excerpt

<title>Abstract</title> <p>Background Inherited cardiomyopathies frequently arise from rare, highly penetrant coding variants with variable clinical expressivity. Recent biobank-scale genome-wide association studies (GWAS) suggest significant polygenic contributions to cardiovascular diseases, including cardiomyopathy. Most GWAS loci map to noncoding regions, which are poorly conserved across species, requiring a...

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Literature Corpus work: 19b55d3a-93a7-5cf7-aab0-42bed34d02a1
DOI: 10.21203/rs.3.rs-7696371/v1

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