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Article

Engineered Heart Tissues Facilitate Noncoding Variant Studies in Cardiomyopathy.

Circulation research - 31 Jul 2026

Weber Zachary T, Monroe Tanner O, Holgren Cory, Mitchell Robert M, Zhang Li, Thornburg Alexis G, Salamone Isabella M, Chychula Ivana A, Karthik Felix, Fullenkamp Dominic E, Puckelwartz Megan J, Liu Xuanyao, McNally Elizabeth M, Nóbrega Marcelo A

Abstract excerpt

BACKGROUND: Cardiomyopathies frequently arise from rare, highly penetrant coding variants with variable clinical expressivity. Genome-wide association studies (GWAS) suggest significant polygenic contributions to cardiovascular diseases, including cardiomyopathy. Most GWAS loci map to poorly conserved noncoding regions, requiring human genome context for experimental validation. METHODS: We created engineered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42366973
DOI: 10.1161/CIRCRESAHA.125.327506

Genes

GRIP2
SLC6A6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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