Single–cell transcriptional and epigenetic mapping reveals cellular and molecular mechanisms driving non-ischemic cardiac fibrosis

Abstract excerpt

<h4>ABSTRACT</h4> Cardiac fibrosis is a major cause of cardiac dysfunction. Recently, single-cell genomic approaches have revealed in unprecedented resolution the orchestrated cellular responses driving cardiac fibrosis. Yet, the fibrosis-causing phenotypes that emerge in the heart following non-ischemic cardiac stress, and the transcriptional circuits that govern cell identity and drive fibrosis, are not well un...

Topics

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• Atherosclerosis and Cardiovascular Diseases
• Cancer-related molecular mechanisms research
• Cardiac Fibrosis and Remodeling
• Congenital heart defects research
• IL-33, ST2, and ILC Pathways
• Peptidase Inhibition and Analysis
• Signaling Pathways in Disease
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

16ebbe89-5741-5788-a020-7e1341f057ac

DOI

10.1101/2024.05.09.593315