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Epigenomes of Human Hearts Reveal New Genetic Variants Relevant for Cardiac Disease and Phenotype.

Circulation research - 28 Aug 2020

Tan Wilson Lek Wen, Anene-Nzelu Chukwuemeka George, Wong Eleanor, Lee Chang Jie Mick, Tan Hui San, Tang Sze Jing, Perrin Arnaud, Wu Kan Xing, Zheng Wenhao, Ashburn Robert John, Pan Bangfen, Lee May Yin, Autio Matias Ilmari, Morley Michael P, Tam Wai Leong, Cheung Christine, Margulies Kenneth B, Chen Leilei, Cappola Thomas P, Loh Marie, Chambers John, Prabhakar Shyam, Foo Roger S Y

Abstract excerpt

RATIONALE: Identifying genetic markers for heterogeneous complex diseases such as heart failure is challenging and requires prohibitively large cohort sizes in genome-wide association studies to meet the stringent threshold of genome-wide statistical significance. On the other hand, chromatin quantitative trait loci, elucidated by direct epigenetic profiling of specific human tissues, may contribute toward...

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Identifiers

PMID: 32529949
DOI: 10.1161/CIRCRESAHA.120.317254
PMCID: PMC10935612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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