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Article

Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure.

Nature communications - 28 Feb 2020

Arvanitis Marios, Tampakakis Emmanouil, Zhang Yanxiao, Wang Wei, Auton Adam, Dutta Diptavo, Glavaris Stephanie, Keramati Ali, Chatterjee Nilanjan, Chi Neil C, Ren Bing, Post Wendy S, Battle Alexis

Abstract excerpt

Heart failure is a major public health problem affecting over 23 million people worldwide. In this study, we present the results of a large scale meta-analysis of heart failure GWAS and replication in a comparable sized cohort to identify one known and two novel loci associated with heart failure. Heart failure sub-phenotyping shows that a new locus in chromosome 1 is associated with left ventricular adverse...

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Identifiers

PMID: 32111823
DOI: 10.1038/s41467-020-14843-7
PMCID: PMC7048760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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