Transcription factor protein interactomes reveal genetic determinants in heart disease.

doi:10.1016/j.cell.2022.01.021

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Article

Transcription factor protein interactomes reveal genetic determinants in heart disease.

Cell - 3 Mar 2022

Gonzalez-Teran Barbara, Pittman Maureen, Felix Franco, Thomas Reuben, Richmond-Buccola Desmond, Hüttenhain Ruth, Choudhary Krishna, Moroni Elisabetta, Costa Mauro W, Huang Yu, Padmanabhan Arun, Alexanian Michael, Lee Clara Youngna, Maven Bonnie E J, Samse-Knapp Kaitlen, Morton Sarah U, McGregor Michael, Gifford Casey A, Seidman J G, Seidman Christine E, Gelb Bruce D, Colombo Giorgio, Conklin Bruce R, Black Brian L, Bruneau Benoit G, Krogan Nevan J, Pollard Katherine S, Srivastava Deepak

Abstract excerpt

Congenital heart disease (CHD) is present in 1% of live births, yet identification of causal mutations remains challenging. We hypothesized that genetic determinants for CHDs may lie in the protein interactomes of transcription factors whose mutations cause CHDs. Defining the interactomes of two transcription factors haplo-insufficient in CHD, GATA4 and TBX5, within human cardiac progenitors, and integrating the...

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Identifiers

PMID: 35182466
DOI: 10.1016/j.cell.2022.01.021
PMCID: PMC8923057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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