Article

Tamoxifen Suppresses Pancreatic β-Cell Proliferation in Mice

2019-03-22

Abstract excerpt

<h4>ABSTRACT</h4> Tamoxifen is a mixed agonist/antagonist estrogen analogue that is frequently used to induce conditional gene deletion in mice using Cre-loxP mediated gene recombination. Tamoxifen is routinely employed in extremely high-doses relative to typical human doses to induce efficient gene deletion in mice. Although tamoxifen has been widely assumed to have no influence upon β-cells, the acute developme...

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Literature Corpus work: 1d74d078-7cd5-504d-88be-40fe80a22b3c
DOI: 10.1101/586602

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