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Article

Postnatal Expansion of the Pancreatic β-Cell Mass Is Dependent on Survivin

4 Jul 2008

Abstract excerpt

OBJECTIVE: Diabetes results from a deficiency of functional beta-cells due to both an increase in beta-cell death and an inhibition of beta-cell replication. The molecular mechanisms responsible for these effects in susceptible individuals are mostly unknown. The objective of this study was to determine whether a gene critical for cell division and cell survival in cancer cells, survivin, might also be important...

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Identifiers

PMID: 18599523
DOI: 10.2337/db08-0170

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