Article
Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone.
Diabetes - 1 Nov 2015
Oropeza Daniel, Jouvet Nathalie, Budry Lionel, Campbell Jonathan E, Bouyakdan Khalil, Lacombe Julie, Perron Gabrielle, Bergeron Valerie, Neuman Joshua C, Brar Harpreet K, Fenske Rachel J, Meunier Clemence, Sczelecki Sarah, Kimple Michelle E, Drucker Daniel J, Screaton Robert A, Poitout Vincent, Ferron Mathieu, Alquier Thierry, Estall Jennifer L
Abstract excerpt
There is growing concern over confounding artifacts associated with β-cell-specific Cre-recombinase transgenic models, raising questions about their general usefulness in research. The inducible β-cell-specific transgenic (MIP-CreERT(1Lphi)) mouse was designed to circumvent many of these issues, and we investigated whether this tool effectively addressed concerns of ectopic expression and disruption of glucose...
Topics
- Animals
- Blood Glucose
- Diabetes Mellitus, Experimental
- Homeostasis
- Human Growth Hormone
- Humans
- Hyperglycemia
- Insulin
- Insulin-Secreting Cells