Article

Tamoxifen Targets Wisp2 to Impair Subcutaneous Adipocyte Progenitor Self-Renewal and Adipogenic Differentiation

2025-12-23

Abstract excerpt

<h4>ABSTRACT</h4> Breast cancer endocrine therapy, which systemically disrupts estrogen receptor signaling, increases type 2 diabetes (T2D) risk in some women. Sustained treatment with low-dose tamoxifen depletes subcutaneous adipocyte progenitors and promotes glucose intolerance and hepatic lipid deposition in obese female mice. Hyperplastic adipose tissue expansion, especially in subcutaneous depots, preserves...

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Identifiers and source

Literature Corpus work: 67837a06-971f-59bb-bcde-39464ba14aa7
DOI: 10.64898/2025.12.21.695772

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