Article

FOXM1 acts sexually dimorphically to regulate functional β-cell mass

2023-01-12

Abstract excerpt

The transcription factor FOXM1 regulates β-cell proliferation and insulin secretion. Our previous work demonstrates that expressing an activated form of FOXM1 (FOXM1*) in β cells increases β-cell proliferation and mass in aged male mice. Additionally, FOXM1* enhances β-cell function even in young mice, in which no β-cell mass elevation occurs. Here, we demonstrate that FOXM1 acts in a sexually dimorphic manner in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1a41749e-ece7-57e7-a4e9-323ceb77a84f
DOI: 10.1101/2023.01.12.523673

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

FOXM1 acts sexually dimorphically to regulate functional β-cell massDOI 10.1101/2023.01.12.523673Read

FoxM1 Is Up-Regulated by Obesity and Stimulates β-Cell ProliferationSemantic proximity Read

Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-CellsSemantic proximity Read

Pancreatic β-cell specific loss of <i>E2f1</i> impairs insulin secretion and β-cell identity through the epigenetic repression of non β-cell programsSemantic proximity Read

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feedingSemantic proximity Read

Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell.Semantic proximity Read

Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function.Semantic proximity Read

MAFA Phosphorylation Controls Beta-Cell Identity and Sex-Specific Pancreatic Disease OutcomesSemantic proximity Read

Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in malesSemantic proximity Read

Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing β-cells to a δ-like fate and reveals a facultative proliferative capacity in aged β-cellsSemantic proximity Read

Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell FunctionSemantic proximity Read

Induction of Core Circadian Clock Transcription Factor Bmal1 Enhances β-Cell Function and Protects Against Obesity-Induced Glucose IntoleranceSemantic proximity Read

Conditional deletion of Men1 in the pancreatic β-cell leads to glucagon-expressing tumor development.Semantic proximity Read