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Article

A Smad Signaling Network Regulates Islet Cell Proliferation

3 Oct 2013

Abstract excerpt

Pancreatic β-cell loss and dysfunction are critical components of all types of diabetes. Human and rodent β-cells are able to proliferate, and this proliferation is an important defense against the evolution and progression of diabetes. Transforming growth factor-β (TGF-β) signaling has been shown to affect β-cell development, proliferation, and function, but β-cell proliferation is thought to be the only source...

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PMID: 24089514
DOI: 10.2337/db13-0432

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