Unexpected effects of the MIP-CreERtransgene and tamoxifen onβ-cell growth in C57Bl6/J male mice

Abstract excerpt

Transgenic mouse models have been fundamental in the discovery of factors that regulate β-cell development, mass, and function. Several groups have recently shown that some of these models display previously uncharacterized phenotypes due to the transgenic system itself. These include impaired islet function and increased β-cell mass due to the presence of a human growth hormone (hGH) minigene as well as impaired...

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