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A human beta cell line with drug inducible excision of immortalizing transgenes

24 Oct 2015

Abstract excerpt

OBJECTIVES: Access to immortalized human pancreatic beta cell lines that are phenotypically close to genuine adult beta cells, represent a major tool to better understand human beta cell physiology and develop new therapeutics for Diabetes. Here we derived a new conditionally immortalized human beta cell line, EndoC-βH3 in which immortalizing transgene can be efficiently removed by simple addition of tamoxifen....

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PMID: 26909308
DOI: 10.1016/j.molmet.2015.09.008

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