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Article

Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell.

Molecular endocrinology (Baltimore, Md.) - 1 Aug 2010

Gao Nan, Le Lay John, Qin Wei, Doliba Nicolai, Schug Jonathan, Fox Alan J, Smirnova Olga, Matschinsky Franz M, Kaestner Klaus H

Abstract excerpt

Foxa1 and Foxa2 play both redundant and distinct roles in early pancreas development. We demonstrate here that inducible ablation of both transcription factors in mature mouse beta-cells leads to impaired glucose homeostasis and insulin secretion. The defects in both glucose-stimulated insulin se...

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Identifiers

PMID: 20534694
DOI: 10.1210/me.2009-0513
PMCID: PMC2940470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20534694-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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