Article
Controlling gene activation by enhancers through a drug-inducible topological insulator
2019-01-29
Abstract excerpt
While regulation of gene-enhancer interaction is better understood, its application remains limited. Here, we reconstituted arrays of CTCF binding sites and devised a s ynthetic t opological insulator with t etO for ch romatin-engineering (STITCH). By coupling STITCH with tetR linked to the KRAB domain to induce heterochromatin and disable the insulation, we developed a drug-inducible system to control gene ac...
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Identifiers and source
- Literature Corpus work
- 1d62abb7-ceb8-5edf-be14-e8d9cfee9d78
- DOI
- 10.1101/534073